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Symbol Name ID |
Vhl
von Hippel-Lindau tumor suppressor MGI:103223 |
| Darker colors indicate more annotations |
| Human Phenotypes | Cerebral hemorrhage |
Retinal capillary hemangioma |
Renal artery stenosis |
Varicose veins |
Stroke |
Hypotension |
Hypertension |
Episodic hypertension |
Positive regitine blocking test |
Pulmonary arterial hypertension |
Tachycardia |
Congestive heart failure |
Lymphadenopathy |
Hepatosplenomegaly |
Pulmonary capillary hemangiomatosis |
Hypertensive retinopathy |
Hemangioma |
Hepatic hemangioma |
| Disease(s) Associated with VHL | ||||||||||||||||||
| familial erythrocytosis 2 | ||||||||||||||||||
| pancreatic cancer | ||||||||||||||||||
| pheochromocytoma | ||||||||||||||||||
| von Hippel-Lindau disease |
| Mouse Phenotypes | abnormal blood vessel morphology |
increased vascular endothelial cell number |
dilated glomerular capillary |
abnormal retina vasculature morphology |
abnormal kidney vasculature morphology |
abnormal placental labyrinth vasculature morphology |
abnormal angiogenesis |
increased angiogenesis |
abnormal vitelline vasculature morphology |
dilated vasculature |
increased heart weight |
abnormal heart left ventricle morphology |
hemorrhage |
placenta hemorrhage |
decreased ventricle muscle contractility |
decreased heart rate |
irregular heartbeat |
prolonged QRS complex duration |
prolonged QT interval |
pulmonary hypertension |
increased vascular permeability |
abnormal vasodilation |
cardiomyopathy |
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| Availability | Mouse Genotype | |||||||||||||||||||||||
| Vhltm1Mcs/Vhltm1Mcs | ||||||||||||||||||||||||
| Vhltm1Wml/Vhltm1Wml | ||||||||||||||||||||||||
| Vhltm1.1Jae/Vhl+ | ||||||||||||||||||||||||
| Vhltm1.1Wkr/Vhl+ | ||||||||||||||||||||||||
| Vhltm1Jae/Vhltm1Jae Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Hprt1tm1(Pck1-cre)Vhh/Y Vhltm1Jae/Vhltm1Jae (conditional) |
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| Vhltm1Jae/Vhltm1Jae Tg(KRT14-cre)1Ipc/0 (conditional) |
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| Vhltm1Jae/Vhltm1Jae Tg(Myh6-cre)2182Mds/0 (conditional) |
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| Vhltm1Jae/Vhltm1Jae Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional) |
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| Vhltm1Jae/Vhltm1Jae Tg(NPHS2-cre)295Lbh/? (conditional) |
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| Vhltm1Jae/Vhltm1Jae Tg(Pax6-cre,GFP)2Pgr/0 (conditional) |
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| Vhltm1Lss/Vhltm1.1Lss Tg(ACTB-cre)1Tes/0 (conditional) |
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| Vhltm1Lss/Vhltm1.1Lss Tg(CAG-cre/Esr1*)1Lbe/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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